John K. Wiencke

Genetic predisposition to altered blood cell homeostasis is associated with glioma risk and survival

This study identifies genetic associations between blood cell traits and glioma risk and survival, highlighting immune-mediated mechanisms and subtype-specific effects.

Genome-wide Polygenic Risk Scores Predict Risk of Glioma and Molecular Subtypes

This study develops a novel polygenic risk score (PRS-CS) for glioma that outperforms existing methods, improving risk prediction and subtype classification using genome-wide association study data.

Enhanced cell deconvolution of peripheral blood using DNA methylation for high-resolution immune profiling

The paper enhances cell deconvolution of peripheral blood using DNA methylation to provide high-resolution immune profiling by including 12 leukocyte subtypes and validated libraries.

Assessment of Polygenic Architecture and Risk Prediction based on Common Variants Across Fourteen Cancers

This study assesses polygenicity and risk prediction using common variants across 14 cancers, finding varying numbers of susceptibility variants and risk score effectiveness.

Systematic evaluation and validation of reference and library selection methods for deconvolution of cord blood DNA methylation data

The paper evaluates and validates reference and library selection methods for deconvolving cord blood DNA methylation data, finding that the IDOL library outperforms automatic selection methods.

Cross-cancer pleiotropic associations with lung cancer risk in African Americans

This study identifies three novel genomic regions associated with lung cancer risk in African Americans, showing pleiotropic effects across multiple cancers.