Jacob E. Choby

Combinatorial action of regulatory systems generates colistin heteroresistance

The paper identifies sigmaE as a key regulator of colistin heteroresistance in Enterobacter cloacae, showing that multiple regulatory systems are required for this resistance.

Metabolic heterogeneity coupled with a resistance gene generates antibiotic heteroresistance

The paper shows that glucose availability increases fosfomycin resistance in Enterobacter cloacae by altering GlpT expression and enhancing fosA gene activity.

Translocation of gut commensal bacteria to the brain

This study shows that gut commensal bacteria can translocate to the brain in mice with dysbiosis and neurological disease, correlating with neuroinflammation and protein aggregation.