Daniel M. Chopyk

This paper develops patient-derived ACC tumor constructs to evaluate therapeutic strategies, showing they can test chemotherapies, targeted therapies, and immunotherapies.

This study shows MMP-14 is critical for ACC cell survival and DNA repair, and its inhibition reduces viability and impairs repair mechanisms.

The paper uses single nuclei RNA sequencing to identify replication stress and DNA damage response in adrenocortical carcinoma, suggesting ATR as a potential therapeutic target.

This study shows that gut commensal bacteria can translocate to the brain in mice with dysbiosis and neurological disease, correlating with neuroinflammation and protein aggregation.