Stress-induced Membrane Insertion at the β-Barrel Assembly Machinery Complex Regulates BepA Metalloprotease Activity
Henri Voedts, Phuong Chi Nguyen, Van Son Nguyen, Pauline Leverrier, Bogdan Iuliu Iorga, Seung-Hyun Cho, Han K. Remaut, Jean‐François Collet
The paper identifies a stress-induced membrane insertion mechanism that activates the BepA metalloprotease by displacing its autoinhibitory plug, linking membrane association to protease function.
Nature Communications · Sep 9, 2026Peer-reviewedMicrobiology