Andrew Pattison

This paper creates a spatial atlas of colorectal cancer and normal colon, identifying nine niches and their gene expression profiles, and links stromal changes to tumour differentiation.

This study combines DNA sequencing and gene-expression profiling with clinical data to improve diagnosis of cancer of unknown primary (CUP), identifying potential tissue origins in over a third of cases.

Topconfects ranks differentially expressed genes by confident log fold change effect sizes, improving biological interpretation over p-value-based rankings.

The paper identifies GLD-2 mediated cytoplasmic polyadenylation targets in C. elegans and shows CCF-1 as the major deadenylase for maternal mRNA silencing.