This study identifies SAC competency as the determinant of sensitivity to KIF18A inhibition in SCLC, offering a predictive biomarker for targeted therapies.

Cancer Research Communications · Aug 26, 2026Peer-reviewedCancer Biology

Tumor-hepatocyte crosstalk drives a hepatic lactate-TGF-β axis of CD8⁺ T cell exhaustion and immunotherapy resistance in small-cell lung cancer liver metastases

Amira Z Kazi, Yingying Cao, Chirayu Mohindroo, Abhinav Joshi, Yang Zhang, Yue Huang, Chiori Tabe, Brett Schroeder, Þorkell Andrésson, Ajit Kumar Sharma, Anish Thomas

bioRxiv · Jul 31, 2026 · PreprintCancer Biology

Proteomic Profiling Identifies CLDN3 as a Tumor-Selective Therapeutic Target in Small Cell Lung Cancer

Brett Schroeder, Jae Choi, Alejandro A. Schäffer, Michael Nirula, Yingying Cao, Yang Zhang, Anna-Lena Meinhardt, Hyeokjun Kwon, Hyerim Park, Sangin Lee, Hyo Jin Shin, Hee Geon Park, Hobin Yang, Sungyoul Hong, Parth Desai, , Anish Thomas

The paper identifies CLDN3 as a tumor-selective target in SCLC using proteogenomic analysis and validates its therapeutic potential with a monoclonal antibody.

bioRxiv · Jul 30, 2026 · PreprintCancer Biology

Hepatobiliary Progenitor-like Reprogramming in Liver Metastases

Ajit Kumar Sharma, Nobuyuki Takahashi, Yingying Cao, Abhinav Joshi, Sophie Z. Zhuang, Amira Z Kazi, Michael Nirula, Sarthak Sahoo, Yang Zhang, Rajeswary Kumar, Seemadri Subhadarshini, Kanak Parmar, Melissa R. Mikolaj, Roshan L Shreshta, Tiyam Assadpour, , Anish Thomas

This study identifies hepatobiliary progenitor-like reprogramming in liver metastases, driven by TGF-β and hypoxia, and shows its association with poor survival.

bioRxiv · Jul 1, 2026 · PreprintCancer Biology