Author

R. P. KASHYAP

Saint Louis UniversityORCID 0000-0002-9141-1168Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:cryo-EM· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Edwin AntonyiD· 4 shared Brian B. BothneriD· 3 shared Monika Tokmina‐LukaszewskaiD· 3 shared Kewei ZhaoiD· 2 shared Ritimukta SarangiiD· 2 shared Abhinav VayyetiiD· 1 shared Ahmed E. DhamadiD· 1 shared Brian BennettiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersBiochemistry

Edwin AntonyORCID

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4 papers

Recent·Most cited

A Binuclear Cluster Supports Functional Asymmetry in Dark-Operative Protochlorophyllide Reductase

Kewei Zhao, Rajnandani Kashyap, Macon J. Abernathy, Edwin Antony, Ritimukta Sarangi

This paper identifies a binuclear [Cu2S2] cluster in DPOR that mediates functional asymmetry between its active sites.

bioRxiv · Nov 5, 2026 · PreprintBiochemistry

Cryo-EM structure of a methanogen nitrogenase-PII protein supercomplex

R. P. KASHYAP, Thomas M. Deere, Ahmed E. Dhamad, Melissa Chanderban, Monika Tokmina‐Lukaszewska, Brian B. Bothner, Daniel J. Lessner, Edwin Antony

The paper reports a cryo-EM structure of a nitrogenase-PII supercomplex in methanogens, revealing a metabolite-gated assembly mechanism for nitrogenase inhibition.

Nature · Oct 7, 2026Peer-reviewedBiochemistry

A Phosphorylation Switch Modulates Configurational Codes in the Oncofetal IGF2BP RNA Binding Paralogs

Vikas Kaushik, Vaishnavi Sanjayan, Jenna R. Mattice, Monika Tokmina‐Lukaszewska, Ricarda Törner, Ilan Edelstein, Rahul Chadda, R. P. KASHYAP, Abhinav Vayyeti, Pralambika Roy, Ryan A. Mehl, Richard B. Cooley, Snorri Th. Sigurdsson, Yaakov Levy, Reza Dastvan, , Edwin Antony

This study shows phosphorylation of IGF2BP1 and IGF2BP3 at a conserved serine acts as a configurational switch, altering their RNA binding domain arrangements and affecting mRNA regulation.

bioRxiv · Aug 19, 2026 · PreprintBiochemistry

Cryo-EM captures the coordination of long-range allostery and asymmetric electron transfer by a bi-copper cluster in the nitrogenase-like DPOR complex

Rajnandani Kashyap, Natalie Walsh, Jaigeeth Deveryshetty, Monika Tokmina‐Lukaszewska, Kewei Zhao, Yunqiao J. Gan, Brian M. Hoffman, Ritimukta Sarangi, Brian B. Bothner, Brian Bennett, Edwin Antony

The paper uses Cryo-EM to reveal how asymmetry and allostery coordinate long-range electron transfer in the DPOR enzyme through a bi-copper cluster.

Nature Communications · Apr 24, 2025Peer-reviewedBiochemistry