Kewei Zhao

This paper identifies a binuclear [Cu2S2] cluster in DPOR that mediates functional asymmetry between its active sites.

This study shows hydrogen sulfide increases copper uptake and localization in cells, with copper primarily in the Cu2+ state, using the ZNT1 transporter for import and ATP7A for export.

This paper introduces dEVA, a framework for de novo metalloenzyme design, achieving high catalytic activity without natural templates.

This paper characterizes ferrosomes in Clostridioides difficile as iron-storage organelles containing a redox-sensitive ferrous phosphate biomineral that limits cytosolic ROS activity.

The paper uses Cryo-EM to reveal how asymmetry and allostery coordinate long-range electron transfer in the DPOR enzyme through a bi-copper cluster.