Jaigeeth Deveryshetty

This study identifies a feedback mechanism involving Cdk1/Wee1 signaling that primes and tunes RPA phosphorylation, crucial for cell cycle progression and DNA damage response.

The paper uses Cryo-EM to reveal how asymmetry and allostery coordinate long-range electron transfer in the DPOR enzyme through a bi-copper cluster.

This study reveals how Rad52 sorts and stacks Rad51 at DNA junctions to enhance homologous recombination by promoting Rad51 binding to RPA-coated ssDNA.

This study uses single-molecule techniques to show that RPA partially wraps ssDNA and that phosphorylation at Ser-384 modulates this wrapping.