Ritimukta Sarangi

A Binuclear Cluster Supports Functional Asymmetry in Dark-Operative Protochlorophyllide Reductase

This paper identifies a binuclear [Cu2S2] cluster in DPOR that mediates functional asymmetry between its active sites.

Hydrogen sulfide dynamically upregulates copper uptake and localization

This study shows hydrogen sulfide increases copper uptake and localization in cells, with copper primarily in the Cu2+ state, using the ZNT1 transporter for import and ATP7A for export.

Zero-shot design of a de novo metalloenzyme

This paper introduces dEVA, a framework for de novo metalloenzyme design, achieving high catalytic activity without natural templates.

Ferrosome Organelles Spatially Insulate a Redox-Active Ferrous Phosphate Biomineral from Cytosolic ROS Chemistry

This paper characterizes ferrosomes in Clostridioides difficile as iron-storage organelles containing a redox-sensitive ferrous phosphate biomineral that limits cytosolic ROS activity.

Use of Substrate Analogues and X-ray spectroscopy Reveals an all Ferrous C-Cluster in CO Dehydrogenase

This paper uses X-ray spectroscopy and substrate analogs to determine the redox states and electronic structure of the C-cluster in Ni-Fe CODH, revealing an all-ferrous cluster in its catalytically active states.

Structure of active methyl-CoM reductase, Earth's main methane producer

The paper determines the structure of active Ni(I)-Methyl-CoM reductase, revealing how it catalyzes methane formation and providing insights for methane emission control and biofuel production.

Cryo-EM captures the coordination of long-range allostery and asymmetric electron transfer by a bi-copper cluster in the nitrogenase-like DPOR complex

The paper uses Cryo-EM to reveal how asymmetry and allostery coordinate long-range electron transfer in the DPOR enzyme through a bi-copper cluster.