Author

Ira T. Lott

University of California, Irvine Medical CenterORCID 0000-0002-3107-0752Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:differential expression· 2 Assay:imaging· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Organism:mouse· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Eric W. Doran· 3 shared David B. KeatoriD· 2 shared Katherine Tseung· 2 shared Michael A. YassaiD· 2 shared Michael J Phelan· 2 shared Steven G. PotkiniD· 2 shared Theo G.M. van ErpiD· 2 shared Adam M. BrickmaniD· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersNeuroscience

Eric W. Doran

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Author profile →

3 papers

Recent·Most cited

Spatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer's Disease

Emily Miyoshi, Samuel Morabito, Caden M. Henningfield, Sudeshna Das, Negin Rahimzadeh, Sepideh Kiani Shabestari, Neethu Michael, Nora Emerson, Fairlie Reese, Zechuan Shi, Zhenkun Cao, Shushrruth Sai Srinivasan, Vanessa M. Scarfone, Miguel A. Arreola, Jackie Lu, , Vivek Swarup

This study uses spatial transcriptomics and single-nucleus RNA-seq to compare genetic and sporadic Alzheimer's Disease, finding similar spatial and cell-type specific changes between sporadic AD and AD in Down Syndrome.

Nature Genetics · Nov 22, 2024Peer-reviewedNeuroscience

Brain Amyloid and the Transition to Dementia in Down Syndrome

David B. Keator, Eric W. Doran, Lisa Taylor, Michael J Phelan, Christy L. Hom, Katherine Tseung, Theo G.M. van Erp, Steven G. Potkin, Adam M. Brickman, Herminia Diana Rosas, Michael A. Yassa, Wayne P. Silverman, Ira T. Lott

The paper uses PET scans to identify brain amyloid patterns in individuals with Down syndrome that predict future dementia conversion.

Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · Jan 1, 2020Peer-reviewedNeuroscience

-Florbetapir PET: Towards Predicting Dementia in Adults with Down Syndrome

David B. Keator, Eric W. Doran, Theo G.M. van Erp, Michael J Phelan, Katherine Tseung, Michael A. Yassa, Steven G. Potkin, Ira T. Lott

This paper investigates the use of florbetapir PET to predict dementia in adults with Down syndrome by examining amyloid accumulation and its relationship to AD pathology.

bioRxiv · Feb 12, 2018 · PreprintNeuroscience