-Florbetapir PET: Towards Predicting Dementia in Adults with Down Syndrome

Abstract

1. Background 1. Background 2. Methods 3. Results 4. Discussion 5. Conclusions References Individuals with Down syndrome (DS) have an increasing age-related prevalence of Alzheimers disease (AD). In DS, the triplication of amyloid precursor protein (APP) on chromosome 21 contributes to a life-long accumulation of brain amyloid (A{beta}) [1]. Dyshomeostasis of A{beta} has emerged as one of the most well-validated factors in the pathogenesis of AD [2]. By age 40 years, virtually all individuals with DS have amyloid plaques and tau tangles, hallmark pathologies that are characteristic of sporadic AD in the general population [3]. Dementia, while not inevitable in DS, increases significantly in prevalence with age to over 75% after age 65 years. [ ...