Author

Eric W. Doran

University of California, Irvine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 4

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Organism:human· 4 Research Focus:differential expression· 3 Assay:imaging· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Ira T. LottiD· 3 shared David B. KeatoriD· 2 shared Elizabeth HeadiD· 2 shared Katherine Tseung· 2 shared Michael A. YassaiD· 2 shared Michael J Phelan· 2 shared Steven G. PotkiniD· 2 shared Theo G.M. van ErpiD· 2 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersNeuroscience

Ira T. LottORCID

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4 papers

Recent·Most cited

Apolipoprotein E abundance is elevated in the brains of individuals with Down syndrome-Alzheimer's disease

Clíona Farrell, Yazead Buhidma, Paige Mumford, Wendy Heywood, Jenny Hällqvist, Lisi Flores Aguilar, Elizabeth J. Andrews, Negin Rahimzadah, Orjona Stella Taso, Eric W. Doran, Vivek Swarup, Elizabeth Head, Tammaryn Lashley, Kevin A. Mills, Christina E. Toomey, Frances K. Wiseman

The paper compares proteome and transcriptome changes in DSAD brains to AD and healthy controls, finding elevated APOE in specific cell types.

Acta Neuropathologica · May 19, 2025Peer-reviewedNeuroscience

Spatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer's Disease

Emily Miyoshi, Samuel Morabito, Caden M. Henningfield, Sudeshna Das, Negin Rahimzadeh, Sepideh Kiani Shabestari, Neethu Michael, Nora Emerson, Fairlie Reese, Zechuan Shi, Zhenkun Cao, Shushrruth Sai Srinivasan, Vanessa M. Scarfone, Miguel A. Arreola, Jackie Lu, , Vivek Swarup

This study uses spatial transcriptomics and single-nucleus RNA-seq to compare genetic and sporadic Alzheimer's Disease, finding similar spatial and cell-type specific changes between sporadic AD and AD in Down Syndrome.

Nature Genetics · Nov 22, 2024Peer-reviewedNeuroscience

Brain Amyloid and the Transition to Dementia in Down Syndrome

David B. Keator, Eric W. Doran, Lisa Taylor, Michael J Phelan, Christy L. Hom, Katherine Tseung, Theo G.M. van Erp, Steven G. Potkin, Adam M. Brickman, Herminia Diana Rosas, Michael A. Yassa, Wayne P. Silverman, Ira T. Lott

The paper uses PET scans to identify brain amyloid patterns in individuals with Down syndrome that predict future dementia conversion.

Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · Jan 1, 2020Peer-reviewedNeuroscience

-Florbetapir PET: Towards Predicting Dementia in Adults with Down Syndrome

David B. Keator, Eric W. Doran, Theo G.M. van Erp, Michael J Phelan, Katherine Tseung, Michael A. Yassa, Steven G. Potkin, Ira T. Lott

This paper investigates the use of florbetapir PET to predict dementia in adults with Down syndrome by examining amyloid accumulation and its relationship to AD pathology.

bioRxiv · Feb 12, 2018 · PreprintNeuroscience