Cereblon on Steroids: Beyond the Canonical Ligand Space
Alexander Herrmann, Christopher Heim, Samuel A. Maiwald, Iuliia Boichenko, Martin Neuenschwander, Andreas Oder, Birte Hernandez Alvarez, Andrei N. Lupas, Jens Peter von Kries, Marcus D. Hartmann
This paper expands the known ligand space of Cereblon by identifying new chemically distinct ligands that bind through non-canonical mechanisms.
bioRxiv · Oct 11, 2026 · PreprintBiochemistry