Mads H. Clausen

The paper identifies a Tankyrase scaffolding inhibitor, S8 (ARCher-142), that selectively targets the ARC4 peptide binding domain with 8 µM potency.

The paper presents a morphological profiling dataset of EU-OPENSCREEN bioactive compounds across multiple imaging sites and cell lines, validated for robustness and used to map profiles to activity and toxicity.

This study identifies additional GDSL-hydrolase enzymes beyond CUTIN SYNTHASE-LIKE 1 that contribute to cutin polymerization and remodeling in tomato fruit, revealing spatiotemporal variation in cutin structure.

This paper identifies alligamycin A, a novel antifungal compound from Streptomyces iranensis, and demonstrates its potent antifungal activity against clinically relevant fungi.