Zakarias Kefil Jensen Ogueboule

Rac1 deficiency reduces mitochondrial respiratory capacity, impairs fatty acid metabolism and causes muscle wasting

This study shows that Rac1 deficiency in muscle reduces mitochondrial function and fatty acid metabolism, leading to muscle wasting and highlights potential therapeutic targets for age-related muscle decline.

Plasma proteomics identifies an IL-6 -associated SAA axis linked to muscle wasting and survival in patients with cancer cachexia

The paper identifies an IL-6-associated SAA axis linked to muscle wasting and poor survival in cancer cachexia through plasma proteomics and functional studies.

Decreased food intake contributes to elevated insulin-responsiveness in pre-clinical cancer cachexia

This study shows that reduced food intake in cancer cachexia increases skeletal muscle insulin responsiveness through AKT signaling, independent of tumor presence.

Proteomic and phospho-proteomic longitudinal signatures of human skeletal muscle in lung cancer cachexia

The paper identifies proteomic and phosphoproteomic changes in skeletal muscle of lung cancer patients with cachexia, linking them to muscle wasting and signaling pathways.