This paper introduces ratiometric transcriptional activation to detect protein abundance changes by converting protein degradation into gene expression outputs in live cells.

Cell · Sep 1, 2026Peer-reviewedSynthetic Biology

Development of potent and selective CK1α Molecular Glue Degraders

Qixiang Geng, Zixuan Jiang, Woong Sub Byun, Katherine A. Donovan, Zhe Zhuang, Fen Jiang, Hannah M. Jones, Hlib Razumkov, Michelle T. Tang, Roman C. Sarott, Eric S. Fischer, Steven M. Corsello, Stephen M. Hinshaw, Nathanael S. Gray

This study develops potent and selective CK1α molecular glue degraders through scaffold hopping and structure-activity relationship analysis of a glutarimide-based library.

Journal of Medicinal Chemistry · Jan 28, 2025Peer-reviewedBiochemistry

Discovery of CRBN-dependent WEE1 Molecular Glue Degraders from a Multicomponent Combinatorial Library

Hlib Razumkov, Zixuan Jiang, Kheewoong Baek, Inchul You, Qixiang Geng, Katherine A. Donovan, Michelle T. Tang, Rebecca J. Metivier, Nada Mageed, Pooreum Seo, Zhengnian Li, Woong Sub Byun, Stephen M. Hinshaw, Roman C. Sarott, Eric S. Fischer, Nathanael S. Gray

The paper identifies CRBN-dependent WEE1 molecular glue degraders through combinatorial library screening and medicinal chemistry, providing structural insights into kinase selectivity.

Journal of the American Chemical Society · Nov 5, 2024Peer-reviewedMolecular Biology