Author

Kheewoong Baek

Harvard UniversityORCID 0000-0002-6853-4936Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Assay:proteomics· 1

Frequent Co-Authors

Eric S. FischeriD· 4 shared Katherine A. DonovaniD· 4 shared Nathanael S. GrayiD· 3 shared Anna M. SchmokeriD· 2 shared Julia K. Ryan· 2 shared Rebecca J. MetivieriD· 2 shared Shourya S. Roy BurmaniD· 2 shared Woong Sub ByuniD· 2 shared

Activity by Year

2024-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersBiochemistry

Eric S. FischerORCID

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Author profile →

4 papers

Recent·Most cited

Development of Degraders and 2-pyridinecarboxyaldehyde (2-PCA) as a recruitment Ligand for FBXO22

Tian Qiu, Zhe Zhuang, Woong Sub Byun, Zuzanna Kozicka, Kheewoong Baek, Jianing Zhong, Abby M. Thornhill, Julia K. Ryan, Katherine A. Donovan, Eric S. Fischer, Benjamin L. Ebert, Nathanael S. Gray

This paper develops chemical probes for FBXO22, including a degrader and a recruitment ligand, to enable targeted protein degradation applications.

bioRxiv · Aug 19, 2025 · PreprintBiochemistry

Unveiling the hidden interactome of CRBN molecular glues with chemoproteomics

Kheewoong Baek, Rebecca J. Metivier, Shourya S. Roy Burman, Jonathan W. Bushman, Hojong Yoon, Ryan J. Lumpkin, Julia K. Ryan, Dinah M. Abeja, Megha Lakshminarayan, Hong Yue, Samuel Ojeda, Yuan Xiong, Jianwei Che, Alyssa L. Verano, Anna M. Schmoker, , Eric S. Fischer

The paper identifies 298 protein targets of CRBN-binding molecular glues using a high-throughput affinity purification mass spectrometry workflow and demonstrates a lead compound for the new target PPIL4.

Nature Communications · Jul 24, 2025Peer-reviewedCancer Biology

Structural ubiquitin contributes to K48 linkage-specificity of the HECT ligase Tom1

Katrina Warner, Moritz Hunkeler, Kheewoong Baek, Anna M. Schmoker, Shourya S. Roy Burman, Daan Overwijn, Cyrus Y. Jin, Katherine A. Donovan, Eric S. Fischer

The paper shows that structural ubiquitin contributes to K48 linkage-specificity in Tom1 through a non-canonical binding site identified via cryo-EM.

Cell Reports · May 1, 2025Peer-reviewedBiochemistry

Discovery of CRBN-dependent WEE1 Molecular Glue Degraders from a Multicomponent Combinatorial Library

Hlib Razumkov, Zixuan Jiang, Kheewoong Baek, Inchul You, Qixiang Geng, Katherine A. Donovan, Michelle T. Tang, Rebecca J. Metivier, Nada Mageed, Pooreum Seo, Zhengnian Li, Woong Sub Byun, Stephen M. Hinshaw, Roman C. Sarott, Eric S. Fischer, Nathanael S. Gray

The paper identifies CRBN-dependent WEE1 molecular glue degraders through combinatorial library screening and medicinal chemistry, providing structural insights into kinase selectivity.

Journal of the American Chemical Society · Nov 5, 2024Peer-reviewedMolecular Biology