Karel Talavera

Cinnamaldehyde interacts with the local anesthetic pocket of the NaV 1.5 channel

This study shows that cinnamaldehyde blocks NaV1.5 channels in a voltage-dependent manner, similar to local anesthetics, and identifies key residues involved in this interaction.

Chemical transfection reagents induce intracellular Ca2+ signals in TRPA1-expressing cells

This study shows that chemical transfection reagents alter intracellular Ca2+ signaling and TRPA1 activity in different cell types through TRPA1-dependent and -independent mechanisms.

Direct analytical estimation of thermodynamic parameters of thermo-TRP channels

The paper develops a method to analytically estimate thermodynamic parameters of thermoTRP channels using algebraic calculations based on patch-clamp data.

Activation by statins unveils two putative agonist binding sites in the pore domain of TRPA1

This study identifies two distinct agonist binding sites in TRPA1 activated by statins and shows competitive interactions between agonists and antagonists.

TRPA1 channel activation by synthetic lipid nanoparticles

This study shows that lipid nanoparticles can activate TRPA1 through multiple calcium influx mechanisms, suggesting a new non-canonical activation pathway.

Tactile and pain mechanical sensitivity of the human hand

This study maps mechanical sensitivity across the human palm, finding higher tactile sensitivity in distal areas and inverse correlation between tactile and pain sensitivity.