Indranil Malik

The paper determines the structure of C9orf72 RAN translation initiation complexes and identifies a key RNA-RNA interaction that drives DPR production, suggesting a therapeutic target.

The paper shows that ribosomal quality control factors reduce toxic repeat-associated non-AUG translation from GC-rich repeats by preventing ribosomal stalling.

This study investigates thiolutin's mode of action, showing it directly inhibits RNA Polymerase II in vitro but has complex in vivo effects involving oxidative stress and metal interactions.

This study shows that DENR/MCTS1 knockdown inhibits RAN translation of expanded repeats and improves Drosophila survival.

The paper identifies RAN translation modifiers and suppressors of repeat toxicity by studying CGG repeat RNA-binding proteins in vivo.

The paper investigates promoter scanning by Pol II in yeast, showing that it occurs across all promoters and is influenced by Pol II activity and promoter architecture.

The paper investigates the effects of altered Pol II catalytic activity on gene expression in yeast, finding unexpected results regarding elongation rates and mRNA stability.