Author

Ross T. Kaufhold

University of MichiganORCID 0000-0002-2589-2709Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:CUT&Tag· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Amy Krans· 2 shared Indranil MalikiD· 2 shared Jailson Brito QueridoiD· 2 shared Peter K. ToddiD· 2 shared Wenzhao Dong· 2 shared Abdurrahman KeskiniD· 1 shared Ahmed A. Abdou· 1 shared Andrew A. PereziD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMolecular Biology

Amy Krans

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Author profile →

3 papers

Recent·Most cited

Structural basis for repeat-associated non-AUG translation initiation on C9orf72 mRNA

Ross T. Kaufhold, Wenzhao Dong, Ishita Purwar, Brenna A Saladin, Clare M. Wieland, Amy Krans, Erinn L. Laimon-Thomson, Indranil Malik, Suada Leskaj, Tal Havilio, Masaaki Sokabe, Christopher S. Fraser, Peter K. Todd, Jailson Brito Querido

The paper determines the structure of C9orf72 RAN translation initiation complexes and identifies a key RNA-RNA interaction that drives DPR production, suggesting a therapeutic target.

bioRxiv · Oct 28, 2026 · PreprintMolecular Biology

SPIDR: a highly multiplexed method for mapping RNA-protein interactions uncovers a potential mechanism for selective translational suppression upon cellular stress

Erica Wolin, Jimmy K. Guo, Mario R. Blanco, Isabel Nadine Goronzy, Darvesh Gorhe, Wenzhao Dong, Andrew A. Perez, Abdurrahman Keskin, Elizabeth Valenzuela, Ahmed A. Abdou, Carl R. Urbinati, Ross T. Kaufhold, H. Tomas Rube, Jailson Brito Querido, Mitchell Guttman, Marko Jovanović

SPIDR is a high-throughput method for mapping RNA-protein interactions that identifies 4EBP1's role in selectively repressing mRNA translation under mTOR inhibition.

Cell · Jul 22, 2025Peer-reviewedSystems Biology

Ribosomal quality control factors inhibit repeat-associated non-AUG translation from GC-rich repeats

Yi‐Ju Tseng, Amy Krans, Indranil Malik, Xiexiong Deng, Evrim Yildirim, Sinem Seleme Övünç, Elizabeth M.H. Tank, Karen R. Jansen‐West, Ross T. Kaufhold, Nicolás Gómez, Roger B. Sher, Leonard Petrucelli, Sami J. Barmada, Peter K. Todd

The paper shows that ribosomal quality control factors reduce toxic repeat-associated non-AUG translation from GC-rich repeats by preventing ribosomal stalling.

Nucleic Acids Research · Feb 19, 2024Peer-reviewedMolecular Biology