Rachel L. Graham

This study shows that SARS-CoV-2 with impaired nsp14-exonuclease activity has reduced replication, fitness, and pathogenesis, but remains viable in some conditions.

This paper demonstrates that MM3122, a host cell serine protease inhibitor, effectively inhibits SARS-CoV-2 replication and reduces disease severity in mice, both prophylactically and therapeutically.