Author

Andreas Hiergeist

University Hospital RegensburgORCID 0000-0002-3154-0638Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Assay:metabolomics· 1

Frequent Co-Authors

André GessneriD· 2 shared Alix SchwarziD· 1 shared Andreas MamilosiD· 1 shared Andressa V. B. NogueiraiD· 1 shared Anna BrandiD· 1 shared Anna DamanakiiD· 1 shared Avi‐Hai HovaviD· 1 shared Björn E. ClauseniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

André GessnerORCID

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2 papers

Recent·Most cited

E-cadherin maintains oral Langerhans cell barrier surveillance to preserve microbiota-dependent immune homeostasis

Anna Brand, Sarah Angabo, Mariia Antipova, Andressa V. B. Nogueira, Andreas Hiergeist, Philipp Muench, Reem Naamneh, Mai Gara, Matthias Klein, Anna Damanaki, Tobias Bopp, James Deschner, André Gessner, Avi‐Hai Hovav, Björn E. Clausen

This study shows that E-cadherin in oral Langerhans cells maintains dendritic morphology and microbiota-dependent immune homeostasis, preventing dysbiosis and inflammation.

bioRxiv · Jul 11, 2026 · PreprintImmunology

A microbial metabolite protects against graft-versus-host disease via mTORC1 and STING-dependent intestinal regeneration

Sascha Göttert, Erik Thiele Orberg, Kaiji Fan, Paul Heinrich, Diana M. Matthe, Omer Khalid, Lena Klostermeier, Chiara Suriano, Nicholas Strieder, Claudia Gebhard, Eva Vonbrunn, Andreas Mamilos, Daniela D. Hirsch, Elisabeth Meedt, Karin Kleigrewe, , Hendrik Poeck

This study identifies desaminotyrosine (DAT) as a microbial metabolite that protects against graft-versus-host disease by promoting intestinal regeneration and modulating immune responses.

Nature Communications · Oct 20, 2025Peer-reviewedImmunology