Tobias Bopp

Macrophage-mediated bystander T cell activation in varicose veins

This study identifies macrophage-mediated cytokine activation of T cells in varicose veins, highlighting a potential therapeutic target for chronic venous insufficiency.

E-cadherin maintains oral Langerhans cell barrier surveillance to preserve microbiota-dependent immune homeostasis

This study shows that E-cadherin in oral Langerhans cells maintains dendritic morphology and microbiota-dependent immune homeostasis, preventing dysbiosis and inflammation.

Oligodendrocyte subtype diversity underlines clinical progression in Parkinsons disease

The paper identifies oligodendrocyte subtype changes in Parkinson's disease across species, linking them to disease progression and clinical outcomes.

B cells maintain the homeostasis of splenic marginal zone antigen-presenting cells to promote the anti-viral CD8+ T cell response

This study shows B cells sustain Langerin+ cDC1s via LTβ and MMMs to support anti-viral CD8+ T cell responses during MCMV infection.

Non-invasive visualization of pH changes within the tumor-micro-environment by positron emission tomography

This paper develops a PET-based method to visualize pH changes in the tumor microenvironment using [18F]FDG-4MBA, showing it can detect small pH differences in different tumors in the same mouse.

CREB REGULATES FOXP3+ST-2+ TREGS WITH ENHANCED IL-10 PRODUCTION

This study shows that CREB knockout in Foxp3+ Tregs increases IL-10 and ST-2 expression, enhancing their suppressive function and preventing gut inflammation.

Single-cell chromatin landscape and DNA methylation patterns reveal shared molecular programs in human tumor and non-tumor tissue CCR8+ Treg cells

The paper compares CCR8+ Treg cells in tumor and tumor-free tissues using chromatin accessibility and DNA methylation, finding high similarity suggesting tumor microenvironment activation of tissue Treg cells.