The VapBC Toxin Antitoxin System Enhances Shigella flexneri Fitness Through Coordination of Metabolic Stress Adaptation and Virulence
Estelle Saifi, Elisabeth Ageron, Keith T. Egger, Caroline Reisacher, Eric Frapy, Morgan Lambérioux, Shelley M. Payne, Jost Enninga, Laurence Arbibe
This study shows the VapBC toxin-antitoxin system in Shigella flexneri enhances bacterial fitness by coordinating metabolic stress adaptation, virulence, and immune evasion during infection.
bioRxiv · Jun 29, 2025 · PreprintMicrobiology