Jost Enninga

The paper identifies and functionally characterizes regulatory variants in DPP9 associated with severe COVID-19 by analyzing genetic risk factors and their impact on gene expression and immune cell function.

The paper shows primary cilia on kidney tubular cells initiate a fibro-inflammatory program in response to bacterial components, linking pathogen detection to kidney disease progression.

This study identifies nitrate-induced intracytoplasmic membranes in Mycobacterium tuberculosis that help dampen inflammation during infection.

This paper introduces cryo-SXT as an intermediate technique to bridge the resolution gap in cryo-CLEM by providing 3D cellular context to cryo-ET datasets.

This study shows the VapBC toxin-antitoxin system in Shigella flexneri enhances bacterial fitness by coordinating metabolic stress adaptation, virulence, and immune evasion during infection.

This study identifies mechanoporation via the Type Three Secretion System as a mechanism by which Shigella flexneri breaches vacuolar membranes to access the cytosol.

This study identifies SifA as a key effector that prevents Salmonella dormancy by promoting nutrient accessibility through SIF-mediated remodeling of the Salmonella-containing vacuole.

This paper develops a single domain antibody targeting ACE2 that protects against SARS-CoV-2 infection in mice when delivered intranasally.

The paper shows that Ca2+ influx regulates actin dynamics and myosin II/VI activity to facilitate Shigella vacuole rupture.

This study identifies factors influencing DNA methylation variation in human blood, showing that cytomegalovirus infection and aging drive methylation changes, with cellular composition and DNA sequence as key predictors.

The paper identifies novel genetic and non-genetic factors associated with plasma protein levels in healthy donors, highlighting their impact on immune response variability.