Darren Wethington

This study shows that NK cell receptor signaling and activation vary with cell cycle stages, with some proteins showing non-monotonic abundance changes.

McSNAC approximates first-order signaling networks from mass cytometry data and shows accuracy in reconstructing models and predicting perturbation outcomes.

This paper applies persistent homology to cytometry data to identify structural differences between healthy donors and COVID-19 patients, revealing downregulation of T-bet and Eomes in patient non-naive CD8+ T cells.

The paper uses mathematical modeling to show that adaptive immunity significantly reduces RSV titer in cotton rats, with key kinetic features observed in both in vitro and in vivo experiments.