Pancreatic islets undergo functional and morphological adaptation during development of Barth Syndrome
Christopher Carlein, Markus D. A. Hoffmann, Caroline Bickelmann, Andressa G. Amaral, Ahmadali Lotfinia, Laurie-Anne de Selliers, Johanne Audouze-Chaud, Selina Wrublewsky, Marcel A. Lauterbach, Karina von der Malsburg, Martin van der Laan, Monika Bozem, Markus Hoth, Patrick Gilon, Magalie A. Ravier, , Letícia Prates Roma
The paper investigates how defective cardiolipin remodeling in Barth Syndrome affects pancreatic islet function and metabolism, finding improved glucose tolerance and compensatory metabolic adaptations in a mouse model.
Diabetologia · Oct 24, 2025Peer-reviewedPhysiology