Markus Hoth

R-CHOP in B cell non-Hodgkin lymphoma: balancing anti-tumor efficacy and NK-cell functionality

This study evaluates the impact of R-CHOP chemotherapy on NK cell viability and function in DLBCL cell lines and patients, finding that treatment reduces NK cell numbers but preserves their cytotoxicity.

Pancreatic islets undergo functional and morphological adaptation during development of Barth Syndrome

The paper investigates how defective cardiolipin remodeling in Barth Syndrome affects pancreatic islet function and metabolism, finding improved glucose tolerance and compensatory metabolic adaptations in a mouse model.

Revisiting the role of microtubules in cytotoxic T cell function: efficient search and killing without microtubule network

This study shows that disrupting microtubules in cytotoxic T cells enhances their migration and target cell elimination in 3D environments.

Mitochondrial reactive oxygen species cause arrhythmias in hypertrophic cardiomyopathy

This study shows that mitochondrial reactive oxygen species contribute to arrhythmias in hypertrophic cardiomyopathy by disrupting calcium handling and electrical conduction.