Author

Alexander G. Nickel

Universitätsklinikum WürzburgORCID 0000-0002-7761-0769Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Christoph MaackiD· 2 shared Alexander DietliD· 1 shared Andrej Kasakow· 1 shared Anja KarlstaedtiD· 1 shared Björn C. KnollmanniD· 1 shared DiyaaElDin AshouriD· 1 shared Dörthe Magdalena KatschinskiiD· 1 shared Ebram Tharwat Melika· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

Christoph MaackORCID

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2 papers

Recent·Most cited

Interferon gamma signaling drives cardiac metabolic rewiring

Ebram Tharwat Melika, DiyaaElDin Ashour, Kyoungmin Kim, Alexander G. Nickel, Paula-Anahi Arias-Loza, Xinyu Chen, Panagiota Arampatzi, Mugdha Srivastava, Martin Väth, Edécio Cunha‐Neto, Michaela Kühn, Georg Gasteiger, Ulrich Hofmann, Takahiro Higuchi, Christoph Maack, , Gustavo Campos Ramos

This study shows that IFN-gamma signaling in cardiomyocytes causes metabolic changes in the heart, including increased glucose uptake and reduced oxidative phosphorylation, which resemble changes in aging and heart failure.

bioRxiv · Aug 31, 2025 · PreprintImmunology

Mitochondrial reactive oxygen species cause arrhythmias in hypertrophic cardiomyopathy

Michael Kohlhaas, Vasco Sequeira, Shan S. Parikh, Alexander Dietl, Olga Richter, Johannes Bay, Edoardo Bertero, Julia Schwemmlein, Xiao Yu Tian, Felix W. Friedrich, Frederik Flenner, Alexander G. Nickel, Felix Michael Alscher, Maithily S. Nanadikar, Raghav Venkataraman, , Christoph Maack

This study shows that mitochondrial reactive oxygen species contribute to arrhythmias in hypertrophic cardiomyopathy by disrupting calcium handling and electrical conduction.

bioRxiv · Oct 2, 2024 · PreprintPhysiology