Michael Kohlhaas

This study evaluates mavacamten's effects on energy balance in RASopathy-associated HCM using hiPSC-CMs with a BRAF mutation.

This study shows that peroxisome dysfunction in mice and engineered human myocardium leads to heart failure through metabolic impairment and disrupted cellular respiration.

This study shows that mitochondrial reactive oxygen species contribute to arrhythmias in hypertrophic cardiomyopathy by disrupting calcium handling and electrical conduction.

The paper shows that IDH2, a mitochondrial enzyme, acts as a major antioxidant defense in cardiomyocytes, with its activity compensating for reduced expression in heart failure, and identifies an epigenetic mechanism linking oxidative stress to cardiac function.