The orientation of cholesterol's hydroxyl group affects its membrane dynamics and intracellular transport
Line Lauritsen, Amanda Therese Pauli, Miklas P.W. Larsen, Peter Reinholdt, Holger A. Scheidt, Yuanjian Xu, Douglas F. Covey, Laura Depta, Hogan P. Bryce-Rogers, Luca Laraia, Jacob Kongsted, Daniel Wüstner
This study shows that the orientation of cholesterol's hydroxyl group affects membrane dynamics and intracellular transport in human astrocytes.
bioRxiv · Feb 4, 2026 · PreprintBiophysics