Yuanjian Xu

Subunit selective modulation of GABAA receptors using pharmacogenetically tethered neurosteroids

The paper develops a DART platform to selectively modulate GABAA receptor subunits using neurosteroids, identifying C11-linked compounds that enhance GABA currents in 4/{delta}-containing receptors.

A Non-Classical Neuroactive Steroid Exhibiting Potent, Efficacious GABA A Receptor Agonism and NMDA Receptor Inhibition

This paper characterizes YX84, a novel neuroactive steroid with dual GABA A receptor agonism and NMDA receptor inhibition, showing favorable behavioral tolerability.

Live-cell imaging and lipidomics of low density lipoprotein containing intrinsically fluorescent cholesteryl esters

This study uses live-cell imaging and lipidomics to track LDL-derived cholesteryl esters in cells, revealing their transport and metabolism kinetics.

The orientation of cholesterol's hydroxyl group affects its membrane dynamics and intracellular transport

This study shows that the orientation of cholesterol's hydroxyl group affects membrane dynamics and intracellular transport in human astrocytes.

Multifaceted Actions of Neurosteroids

The paper investigates the range of actions of neurosteroid analogues using in silico and in vitro methods, revealing unexpected modulation of multiple targets beyond GABA-A receptors.

Endogenous and fluorescent sterols reveal the molecular basis for ligand selectivity of human sterol transporters

The paper profiles fluorescent steroid probes across ten STPs to uncover selectivity differences and establishes a screening panel to identify new Aster-B inhibitors.