Luca Laraia

This study identifies a GlcChol-RAC1-actin signaling axis linking GBA2 loss-of-function to synaptic and mitochondrial dysfunction in SPG46, with Rac1 inhibition rescuing disease phenotypes in a zebrafish model.

This study shows that the orientation of cholesterol's hydroxyl group affects membrane dynamics and intracellular transport in human astrocytes.

The paper profiles fluorescent steroid probes across ten STPs to uncover selectivity differences and establishes a screening panel to identify new Aster-B inhibitors.