Françoise Coussen

This study investigates how 4.1N and SAP97 differentially regulate phases of GluA1 AMPA receptor intracellular transport and exocytosis under basal and cLTP conditions.

The paper identifies TSPAN5 as an adaptor protein that promotes AMPA receptor exocytosis by interacting with AP-4 and Stargazin in rat hippocampal neurons.

This study shows that impaired AMPA receptor surface diffusion contributes to synaptic plasticity and memory deficits in Huntington’s disease, and that tianeptine can restore these functions.