This study shows that adaptation to cystine limitation stress in PDAC promotes tumor growth via lipid metabolism reprogramming, and lomitapide can inhibit this process and enhance chemotherapy.

Nature Communications · Dec 31, 2025Peer-reviewedCancer Biology

Expanded gut microbial genomes from Chinese populations reveal population-specific genomic features related to human physiological traits

Quanbin Dong, Beining Ma, Xiaofeng Zhou, Pan Huang, Mengke Gao, Shuai Yang, Yuwen Jiao, Yan Zhou, Zhun Shi, Qiufeng Deng, Dongxu Hua, Xiuchao Wang, Lu Liu, Chengcheng Zhang, Chuan Zhang, , Lianmin Chen

The paper constructs a comprehensive gut microbiome reference database from Chinese and non-Chinese populations, revealing population-specific microbial features linked to host physiology.

Genome Medicine · Oct 31, 2025Peer-reviewedGenomics

The genetic diversity and populational specificity of the human gut virome at single nucleotide resolution

Xiuchao Wang, Quanbin Dong, Pan Huang, Shuai Yang, Mengke Gao, Chengcheng Zhang, Chuan Zhang, Youpeng Deng, Zijing Huang, Beining Ma, Yuwen Jiao, Yan Zhou, Tingting Wu, Huayiyang Zou, Jing Shi, , Lianmin Chen

The paper characterizes the human gut virome at single nucleotide resolution using a large Chinese dataset, revealing population-specific genetic variations and their associations with health traits.

Microbiome · Aug 20, 2025Peer-reviewedMicrobiology

Food pairing independently associated with cardiometabolic traits beyond dietary patterns across western and eastern populations

Qiufeng Deng, Yuhao Sun, Mingxia Gu, Jingxiang Fu, Fengzhe Xu, Yuwen Jiao, Yan Zhou, Beining Ma, Lu Liu, Xiuchao Wang, Quanbin Dong, Tingting Wu, Huayiyang Zou, Jing Shi, Yifeng Wang, , Lianmin Chen

This study identifies food pairing patterns linked to cardiometabolic traits across populations, showing their independent association beyond single-food effects and dietary indices.

Engineering · Mar 1, 2025Peer-reviewedMicrobiology