Yan Zhou

Catch-bond engineering surpasses high-affinity maturation for T cell receptor therapies against solid tumors

This study shows that catch-bond engineering improves TCR-T cell therapy efficacy against solid tumors without off-target toxicity, surpassing traditional high-affinity maturation strategies.

Molecular basis of high-torque transmission of the Vibrio polar flagellar motor

This study presents an atomic-resolution structure of the Vibrio polar flagellar motor, revealing structural features that enable high-torque transmission and unique motility.

Exome Reanalysis Identifies Novel Candidate Genes Associated with Congenital Anomalies of the Kidney and Urinary Tract in China

This study reanalyzes exome sequencing data from Chinese CAKUT patients to identify four novel candidate genes associated with kidney and urinary tract anomalies.

Healthcare Infrastructure Shapes Evolutionary Trade-offs and Geographic Dissemination of Multidrug-Resistant Acinetobacter baumannii

This study shows how hospital network structure influences the evolution and spread of drug-resistant bacteria, identifying two distinct evolutionary strategies in Acinetobacter baumannii.

The genetic diversity and populational specificity of the human gut virome at single nucleotide resolution

The paper characterizes the human gut virome at single nucleotide resolution using a large Chinese dataset, revealing population-specific genetic variations and their associations with health traits.

A genome-scale single cell CRISPRi map of trans gene regulation across human pluripotent stem cell lines

The paper presents a genome-scale CRISPRi perturbation map in human pluripotent stem cells using single-cell RNA sequencing to study trans gene regulation across diverse genetic backgrounds.

Minimized double guide RNA libraries enable scale-limited CRISPR/Cas9 screens

This paper introduces a minimized double guide RNA library for CRISPR/Cas9 screens, reducing scale by fivefold while maintaining performance.

Zika Virus in the Human Placenta and Developing Brain: Cell Tropism and Drug Inhibition

This study identifies ZIKV susceptible cell types in placenta and brain, shows antibiotic inhibition of viral proliferation, and suggests mechanisms for congenital ZIKV pathologies.