Katarina E. Heyden

This study shows that β-catenin activation in liver cancer cells reduces mitochondrial pyruvate carrier expression and shifts metabolism from carbohydrate to fatty acid oxidation.

This study compares the effects of tirzepatide and caloric restriction on hematopoiesis in obese mice, finding tirzepatide preserves HSPC cycling and reduces inflammatory monocytes while CR causes cytopenias.

This study identifies SLC16A6 as the melanosomal tyrosine transporter, showing it is essential for melanosome biogenesis and function.

This study shows that vitamin B12 deficiency impairs mitochondrial DNA integrity and oxidative phosphorylation in skeletal muscle, while B12 supplementation improves mitochondrial function in aged mice.

This study shows high folic acid intake increases uracil in DNA and γH2AX foci in colon tissue but not liver in mice with reduced methionine synthase expression.

This study shows that reducing folate intake in aged mice decreases biosynthetic processes but does not compromise healthspan, suggesting age-dependent benefits of folate restriction.