Martha S. Field

This study shows maternal folate levels influence adult hematopoietic stem cell function through mitochondrial and chromatin changes in offspring.

This study shows that vitamin B12 supplementation improves mitochondrial biology in aged mice by increasing mitochondrial content and reducing oxidative stress.

This study shows that vitamin B12 deficiency impairs mitochondrial DNA integrity and oxidative phosphorylation in skeletal muscle, while B12 supplementation improves mitochondrial function in aged mice.

This study shows high folic acid intake increases uracil in DNA and γH2AX foci in colon tissue but not liver in mice with reduced methionine synthase expression.

This study shows that reduced Shmt2 expression causes mtDNA leakage into the cytosol, triggering different downstream effects like apoptosis or activation of the cGAS/STING pathway in different cell types.

The paper investigates how vitamin B12 and folic acid affect mitochondrial DNA heteroplasmy in mice and suggests potential sex-specific effects in humans.

This study shows that reducing folate intake in aged mice decreases biosynthetic processes but does not compromise healthspan, suggesting age-dependent benefits of folate restriction.