Christiana Ruhrberg

The paper identifies a Csf1r lineage contributing to 60% of embryonic dermal lymphatic endothelial cells and shows its necessity for normal lymphatic development.

The paper identifies novel molecular markers for haemogenic endothelium and haematopoietic progenitors in mouse yolk sac using single-cell RNA sequencing and pseudotime analysis.

The paper shows that neurovascular signals guide adrenal gland compartmentalization by shaping vascular domains that direct hormone-producing cells to their correct territories.

This study identifies two progenitor sources for kidney lymphatics in mice: Tie2 endothelial lineage and Osr1 intermediate mesoderm, showing a dual origin for kidney lymphatic formation.

This study shows that CreER activation in mice impairs angiogenesis by slowing endothelial proliferation, with effects recovering after tamoxifen discontinuation.

The paper identifies a transient population of Pax3 lineage cells in the mouse fetal liver and circulation with haematopoietic progenitor characteristics and the ability to generate myeloid and erythroid cells.

This study shows that motor nerves guide the development of sympathetic ganglia by directing the migration and differentiation of neural crest-derived sympathoblasts.

BulkECexplorer compiles bulk RNAseq data from vascular endothelial cells to predict gene activity or leakiness across five subtypes.

The paper identifies NRP1-expressing myeloid cells as promoters of arteriogenesis in ischemic limbs and suggests their therapeutic potential.

This study shows VEGF inhibits arterial specification in capillaries by suppressing Sox17, preventing premature arterialization driven by shear stress.

This study shows that EG00229, designed to inhibit VEGF-NRP1 interaction, paradoxically increases vascular leakage by activating NRP1-dependent signaling pathways.

The paper generates a refined single-cell landscape of haematopoiesis in the mouse foetal liver using scRNA-seq, identifying new cell populations and transcriptional dynamics.

This study shows that tamoxifen treatment in male mice increases morbidity and mortality when combined with medetomidine or dexmedetomidine anaesthesia.

The paper shows KIT is required for fetal liver erythropoiesis but not for yolk sac endoHT or brain angiogenesis.