Victoria S Rashbrook

Molecular and Structural Basis of Cardiac Remodelling in Niemann-Pick Type C

This study identifies cardiac involvement in Niemann-Pick type C through ECG abnormalities, fibrosis, and transcriptomic changes in patients and Npc1-/- mice.

CreER activation transiently impairs angiogenesis by slowing endothelial proliferation

This study shows that CreER activation in mice impairs angiogenesis by slowing endothelial proliferation, with effects recovering after tamoxifen discontinuation.

Lysosomal calcium signalling contributes to the acute α-adrenergic response via calcium-stimulated adenylyl cyclase 1 and 8

This study shows that lysosomal calcium signaling via NAADP and calcium-stimulated adenylyl cyclase 1 and 8 contributes to the acute α-adrenergic response in atrial myocytes.

Tamoxifen exacerbates morbidity and mortality in mice receiving medetomidine anaesthesia

This study shows that tamoxifen treatment in male mice increases morbidity and mortality when combined with medetomidine or dexmedetomidine anaesthesia.