Jasmine X. Y. Khor

This study identifies PRDM9 as a factor promoting survival of drug-tolerant persister cells in glioblastoma through metabolic rewiring and cholesterol biosynthesis.

The paper identifies very long-chain ceramides in muscle as independently associated with insulin resistance, separate from adiposity effects, using genetic variation in mice.

This study shows that mice lacking CerS2 in oligodendrocytes develop myelin instability, microglial activation, and early lethality due to reduced C22-C24 sphingolipids.