Anna Ermund

Proteomic analysis of bronchoalveolar lavage fluid after lung transplantation associates stable allograft function with less lung damage at 12 months

The paper identifies proteomic differences in bronchoalveolar lavage fluid at 12 months post-lung transplant that correlate with stable graft function versus early chronic lung allograft dysfunction.

Structural mechanism of MUC5AC mucin net-like polymer formation and its SNP variability that affect risk of the lung diseases COPD and IPF

The paper determines the cryoEM structures of MUC5AC variants and shows their structural basis for mucus formation and disease risk in COPD and IPF.

Anion exchange regulates intestinal mucus expansion while Cftr regulates de novo mucus secretion

This study investigates the roles of anion exchange and Cftr in regulating mucus expansion and secretion in the colon and ileum, finding that anion exchange controls expansion while Cftr mediates de novo secretion.

COPD lungs show an attached stratified mucus layer resembling the protective colonic mucus

The paper compares mucus composition and structure in COPD, CF, and colonic mucus, finding similarities in proteomes and a protective attached mucus layer in the lungs.