Sergio Trillo‐Muyo

Degradation of the intestinal mucus layer by the ETEC protease EatA is species specific determined by the structure of the MUC2 mucin

The paper shows ETEC protease EatA degrades human MUC2 mucin specifically, enabling bacterial infection by disrupting the intestinal mucus layer.

Cryo-EM structure of CLCA1 identifies CLCA1 as a founding member of a novel metzincin family.

The paper determines the Cryo-EM structure of CLCA1, revealing its unique domain organization and regulatory mechanisms, and identifies it as a founding member of a new metzincin family.

Structural mechanism of MUC5AC mucin net-like polymer formation and its SNP variability that affect risk of the lung diseases COPD and IPF

The paper determines the cryoEM structures of MUC5AC variants and shows their structural basis for mucus formation and disease risk in COPD and IPF.

BPP43_05035 is a Brachyspira pilosicoli cell surface adhesin that weakens the integrity of the epithelial barrier during infection

This study identifies BPP43_05035 as a Brachyspira pilosicoli adhesin that disrupts epithelial tight junctions, increasing barrier permeability during infection.