Gunnar C. Hansson

Airway Secretory Cells Contain Both a Perinuclear Golgi Ribbon and Dispersed Golgi Satellites

The paper examines the Golgi structure in airway secretory cells, finding a unique combination of a perinuclear Golgi ribbon and dispersed Golgi satellites, independent of mucin production levels.

Degradation of the intestinal mucus layer by the ETEC protease EatA is species specific determined by the structure of the MUC2 mucin

The paper shows ETEC protease EatA degrades human MUC2 mucin specifically, enabling bacterial infection by disrupting the intestinal mucus layer.

Proteomic analysis of bronchoalveolar lavage fluid after lung transplantation associates stable allograft function with less lung damage at 12 months

The paper identifies proteomic differences in bronchoalveolar lavage fluid at 12 months post-lung transplant that correlate with stable graft function versus early chronic lung allograft dysfunction.

Structural mechanism of MUC5AC mucin net-like polymer formation and its SNP variability that affect risk of the lung diseases COPD and IPF

The paper determines the cryoEM structures of MUC5AC variants and shows their structural basis for mucus formation and disease risk in COPD and IPF.

COPD lungs show an attached stratified mucus layer resembling the protective colonic mucus

The paper compares mucus composition and structure in COPD, CF, and colonic mucus, finding similarities in proteomes and a protective attached mucus layer in the lungs.