Christopher M. Evans

This study shows that mucin promotes pneumococcal colonization by suppressing autolysis and modulating immune responses through tryptophan biosynthesis.

This study shows Muc5ac is critical for antiviral defense but also necessary for virus-induced airway hyperresponsiveness in mice.

This study shows that amoxicillin causes long-term gut dysbiosis and reduces type-17 immune tone in the lungs.

The paper examines the Golgi structure in airway secretory cells, finding a unique combination of a perinuclear Golgi ribbon and dispersed Golgi satellites, independent of mucin production levels.

This study shows that Siglec-F protects against elastase-induced lung inflammation and emphysema by regulating airspace macrophages in mice.

This study shows that Siglec-F deficiency reduces fibrosis in bleomycin-induced lung injury by altering gene expression in airspace macrophages.

This study identifies fucosyltransferase 2 (Fut2) as essential for mucin fucosylation, which contributes to allergic airway hyperreactivity and mucus obstruction in mice.

The paper compares mucus composition and structure in COPD, CF, and colonic mucus, finding similarities in proteomes and a protective attached mucus layer in the lungs.