Clara Aabye Madsen

This study compares CSF-to-brain tracer exchange in pigs under two anesthetic regimens, finding higher tracer accumulation with ketamine/dexmedetomidine compared to propofol.

This study uses SPECT/CT to compare CSF dynamics in pigs and rats under different anesthetics, finding species- and anesthesia-specific differences in tracer distribution and clearance.

This paper develops kinetic models for PET displacement studies to estimate target occupancy from a single scan, showing good agreement with traditional methods.

This paper evaluates the PET radiotracer (d3)-[11C]MODAG-001 in pigs to detect α-synuclein aggregates, showing increased binding in regions with α-synuclein pre-formed fibrils and Alzheimer's homogenate.

The paper develops a pig model for testing PET radioligands targeting cerebral protein aggregates, validated using [11C]PIB uptake in injected regions.