This study compares CSF-to-brain tracer exchange in pigs under two anesthetic regimens, finding higher tracer accumulation with ketamine/dexmedetomidine compared to propofol.

bioRxiv · Aug 27, 2026 · PreprintNeuroscience

Scaling of anesthesia-dependent cerebrospinal fluid dynamics across rat and pig brains

Natalie Beschörner, Miriam L. Navarro, Marko Rosenholm, Björn Sigurðsson, Nakul Ravi Raval, Emily Eufaula Beaman, Sara Marie Ulv Larsen, Louise Møller Jørgensen, Clara Aabye Madsen, Visti Hildebrandt Stenmo, Gerda Krog Thomsen, Kristoffer Brendstrup‐Brix, Claus Svarer, Maiken Nedergaard, Gitte M. Knudsen

This study uses SPECT/CT to compare CSF dynamics in pigs and rats under different anesthetics, finding species- and anesthesia-specific differences in tracer distribution and clearance.

bioRxiv · Jul 30, 2026 · PreprintNeuroscience

Evaluation of the α-synuclein PET radiotracer (d3)-MODAG-001 in pigs

Nakul Ravi Raval, Clara Aabye Madsen, Vladimir Shalgunov, Arafat Nasser, Umberto Maria Battisti, Emily Eufaula Beaman, Morten Juhl, Louise Møller Jørgensen, Matthias M. Herth, Hanne Demant Hansen, Pontus Plavén‐Sigray, Gitte M. Knudsen

This paper evaluates the PET radiotracer (d3)-[11C]MODAG-001 in pigs to detect α-synuclein aggregates, showing increased binding in regions with α-synuclein pre-formed fibrils and Alzheimer's homogenate.

Nuclear Medicine and Biology · Aug 24, 2022Peer-reviewedNeuroscience

An in vivo pig model for testing novel PET radioligands targeting cerebral protein aggregates

Nakul Ravi Raval, Arafat Nasser, Clara Aabye Madsen, Natalie Beschörner, Emily Eufaula Beaman, Morten Juhl, Szabolcs Lehel, Mikael Palner, Claus Svarer, Pontus Plavén‐Sigray, Louise Møller Jørgensen, Gitte M. Knudsen

The paper develops a pig model for testing PET radioligands targeting cerebral protein aggregates, validated using [11C]PIB uptake in injected regions.

bioRxiv · Dec 31, 2021 · PreprintNeuroscience