Claus Svarer

This study compares CSF-to-brain tracer exchange in pigs under two anesthetic regimens, finding higher tracer accumulation with ketamine/dexmedetomidine compared to propofol.

This study uses SPECT/CT to compare CSF dynamics in pigs and rats under different anesthetics, finding species- and anesthesia-specific differences in tracer distribution and clearance.

This study predicts brain age using 5-HT2AR PET and MRI data, finding that combining both improves accuracy compared to using either modality alone.

This study replicates a positive association between serotonin 2A receptor binding and inward facets of neuroticism using the [11C]Cimbi-36 tracer and finds no moderating effect of cortisol awakening response.

This paper develops kinetic models for PET displacement studies to estimate target occupancy from a single scan, showing good agreement with traditional methods.

The paper develops a pig model for testing PET radioligands targeting cerebral protein aggregates, validated using [11C]PIB uptake in injected regions.

The paper creates a high-resolution in vivo atlas of benzodiazepine receptor densities in the human brain using PET and autoradiography data, linking it to GABAAR subunit mRNA expression.

The paper investigates the effects of dorsal striatal dopamine activation on CSTC circuit function in rats, finding reduced fronto-cortical activity and changes in behaviors related to anxiety and compulsive actions.