Martin Schain

This paper develops kinetic models for PET displacement studies to estimate target occupancy from a single scan, showing good agreement with traditional methods.

This study shows that amphetamine differentially affects D1R and D2R internalization and recycling in nonhuman primates, with D1R showing excitatory signaling and D2R remaining internalized after repeated administration.

The paper investigates the effects of dorsal striatal dopamine activation on CSTC circuit function in rats, finding reduced fronto-cortical activity and changes in behaviors related to anxiety and compulsive actions.

This study evaluates the validity and reliability of [11C]raclopride PET for quantifying D2/3R binding outside the striatum, finding it unreliable in extrastriatal regions.

This study evaluates the accuracy and reliability of specific binding estimates for [11C]PBR28 using the SIME method, showing good precision and reliability for VS but variability in BPND.